From the main Search & Destroy menu, click the Check for Problems button to start your search.

Your scan will then commence. The scan may take a few minutes depending on the speed of your computer. You can watch it's progress from the progress bar in the lower portion of the menu.

After your search is complete make sure ALL the search results are checked.
 Click the Fix Selected Problems button on the menu above.

You will then be prompted to confirm your selections. Hit the Yes button and the selected items will begin to be removed. This may take a moment depending on the speed of your computer, but you can monitor its progress on the bar at the bottom of the screen.

When finished, the program will inform you that a certain number of results were successfully fixed.
 Click OK to finish the scanning process.

Now click the Spybot - S & D header on the left hand menu to return to the main Spybot screen.