Locate the Program in the Start Menu.
If running for the first time, it will prompt you to check for updates, click on check for updates.
To perform a scan, click on scan in the top toolbar.
Allow the program to search your computer for any known spyware issues.
Upon completion it will either say your computer is fine and nothing was detected, or prompt you to remove any found traces of spyware. Follow the directions onscreen if anything was detected.
Your computer is now protected and you can close out the program. Run a scan frequently to keep your computer spyware free.
You will also want to update your spyware definitions frequently as well, if it doesn't prompt you to check for updates,
you can manually check on the main screen by hitting the check for updates now button.